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IV Infusions

Continuing your
ENTYVIO treatment
by IV

When do maintenance
doses happen?

Maintenance doses are given after the intravenous (IV) infusion starter doses. Maintenance doses can be administered either through IV or with the ENTYVIO Pen. You and your healthcare provider will discuss which option is right for you. This page walks through the experience of receiving maintenance doses by IV.

Treatment Schedule

What are maintenance doses like?

Your healthcare provider will administer ENTYVIO through a needle placed in a vein in your arm, either at their office, at an infusion center, or in your home. Infusions last approximately 30 minutes. During and after the infusion, your healthcare provider will monitor you for side effects to see if you have a reaction to the treatment. Take a look at our additional resources for IV treatment.

Each infusion lasts approximately 30 minutes, for a total infusion time of approximately 4 hours in your first year.

Maintenance schedule

After your initial doses, you will continue to receive ENTYVIO by IV every 8 weeks. 

Every 8 Weeks

  • In the first year, you’ll receive 8 doses of ENTYVIO
  • After the first year, you’ll receive 6 doses each year

Safety Considerations

Do not receive ENTYVIO if you have had an allergic reaction to ENTYVIO or any of its ingredients. Infusion-related and serious allergic reactions can happen while you are receiving ENTYVIO or several hours after treatment. ENTYVIO may increase your risk of getting a serious infection.

Please see additional Important Safety Information below.

Find an infusion center

Wondering if there’s an infusion center close to home? Use our Infusion Center Finder to find one that’s convenient for you.

See Locations Near You

Preparing for Treatment Day

A few tips to prepare you for your infusion 

Try to drink a lot of water. Staying hydrated is important.

Get a good night’s sleep. It helps to be well rested.

Wear loose-fitting clothes. Make your infusion as comfortable as possible.

Staying on Track

Staying on track with treatment

EntyvioConnect is a patient support program created to help you at every step of your ENTYVIO journey—including keeping you on track with your infusion schedule. If you haven’t already, sign up for EntyvioConnect to receive resources and access to support from a Nurse Educator, who you can discuss your treatment milestones with. They cannot, however, provide medical advice.

Already signed up for EntyvioConnect? Be sure to opt in to receive reminders via text when it's time for your next dose of ENTYVIO.

Travel Tips

What about traveling?

Traveling can be exciting, but if you plan on being away from home at the time of your next infusion, it may require some additional planning.

If you’re traveling within the United States, you may be able to find a local infusion center—you can ask your healthcare provider for a referral. If you miss or plan to miss an infusion, speak with your healthcare provider as soon as possible about any concerns you may have and to reschedule an appointment.

Real ENTYVIO Patients

Talk to other patients through
Entyvio Connections

Want to chat with others who know what it’s like to receive an infusion? Patient Ambassadors with the Entyvio Connections program know what it's like to live with UC or Crohn's.


There's no substitute for experience. Hear real ENTYVIO patients share what they've learned about handling some of their everyday challenges. Your experience may vary.

Hear advice from real ENTYVIO patients.

Advice from


Click here for Medication Guide

I think it's important to tell new people... that A, it's not your body's fault, it's not your fault for what's happening to you. And B, to get as much support as you can, whether that takes the form of a support group in person, if there is one local to you, or online.

So if you don't face the reality of it, then you can't get past it. You have to be able to admit to yourself, did I really just go to the bathroom ten times in the last five hours? And I have to talk about this. I have to get to that next place that says, how do I not have that happen, and where do I go from here?

My best advice is just share your story with someone else and let them encourage you to, to kind of find that courage from within and take that first step. For me that was a bit of a mind shift to learn to be my own advocate and to really push for the best healthcare that I could get.

We're all unique and we, we need to really to get to know our body because the doctor, he doesn't know your body. He's got all these opportunities to try different things but he doesn't know your body in particular, so you have to help educate him. And, you know, it's really critical to find a doctor that's willing to be a partner with you.

Focus on what you can control. And that is your medication... communication with your doctor.

Humor has been an, a really important, um, when I tell my story I sometimes end it by saying that um, you know laughter really is the best medicine. And it has been for me and I'm grateful to be able laugh at things now.

ENTYVIO is a prescription medicine used in adults with moderately to severely active ulcerative colitis or Crohn's disease when certain other medications have not worked well enough or cannot be tolerated.

Important Safety Information about ENTYVIO® (vedolizumab)

  • Do not receive ENTYVIO if you have had an allergic reaction to ENTYVIO or any of its ingredients.
  • ENTYVIO may cause serious side effects, including:
    • Infusion-related and serious allergic reactions can happen while you are receiving ENTYVIO or several hours after treatment. You may need treatment if you have an allergic reaction. Tell your healthcare provider or get immediate medical help if you get any of these symptoms during or after an infusion of ENTYVIO: rash, itching, swelling of your lips, tongue, throat or face, shortness of breath or trouble breathing, wheezing, dizziness, feeling hot, or palpitations (feel like your heart is racing).
    • ENTYVIO may increase your risk of getting a serious infection. Before receiving and during treatment with ENTYVIO, tell your healthcare provider if you think you have an infection or symptoms of an infection, such as fever, chills, muscle aches, cough, shortness of breath, runny nose, sore throat, red or painful skin or sores on your body, tiredness, or pain during urination.
    • People with weakened immune systems can get progressive multifocal leukoencephalopathy (PML) (a rare, serious brain infection caused by a virus). Although unlikely while receiving ENTYVIO, a risk of PML cannot be ruled out. PML can result in death or severe disability. There is no known treatment, prevention, or cure for PML. Tell your healthcare provider right away if you have any of the following symptoms: confusion or problems thinking, loss of balance, change in the way you walk or talk, decreased strength or weakness on one side of the body, blurred vision, or loss of vision.
    • Liver problems can happen in people who receive ENTYVIO. Tell your healthcare provider right away if you have any of the following symptoms: tiredness, loss of appetite, pain on the right side of your abdomen, dark urine, or yellowing of the skin and eyes (jaundice).
  • The most common side effects of ENTYVIO include common cold, headache, joint pain, nausea, fever, infections of the nose and throat, tiredness, cough, bronchitis, flu, back pain, rash, itching, sinus infection, throat pain, and pain in extremities. These are not all the possible side effects of ENTYVIO. Call your healthcare provider for medical advice about side effects.
  • Before receiving ENTYVIO, tell your healthcare provider about all of your medical conditions, including if you: have or think you may have an infection or have infections that keep coming back; have liver problems; have tuberculosis (TB) or have been in close contact with someone with TB; have recently received or are scheduled to receive a vaccine; or if you are pregnant, breastfeeding, plan to become pregnant, or plan to breastfeed.

Please see accompanying full Prescribing Information, including the Medication Guide, for ENTYVIO and talk with your healthcare provider.

You are encouraged to report negative side effects of prescription drugs to the FDA.

Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Uses of ENTYVIO® (vedolizumab)

ENTYVIO is a prescription medicine used in adults for the treatment of:

  • moderately to severely active ulcerative colitis
  • moderately to severely active Crohn's disease

What does the full ENTYVIO treatment experience look like?

Explore the Journey