Living with CD More Information on Your Condition

Understanding Crohn's Disease

780k
780K
Number of Americans affected by Crohn's disease (CD). CD can occur at any age, but is more prevalent in young adults.

The causes of Crohn's disease

The true causes of Crohn's are not completely understood. What we do know is that if you or a close relative have the disease, your family members may be at an increased chance of Crohn's. Researchers believe that a combination of hereditary, genetic, and/or environmental factors may contribute to the development of Crohn's disease. Diet and stress may aggravate Crohn's disease, but they do not cause the disease on their own.

How Crohn's disease affects you

Crohn's Disease is the result of an abnormal immune system response, during which your body mistakes certain bacteria, and other materials in the intestine for foreign or invading substances. It then sends white blood cells into the intestines, where they create inflammation. Normally, this would cause a temporary inflammation that would resolve itself. But with CD, researchers' believe that once your immune system is "turned on," it doesn't know how to "properly turn off." As a result, chronic inflammation damages the intestine and causes the symptoms of CD.

Crohn's disease can affect the thickness of the bowel wall in any part of the GI tract and the inflammation it causes can "skip"—leaving normal areas in between patches of diseased intestine.
How Crohn's disease may affect you
Crohn's disease most commonly affects the end of the small bowel (the ileum) and the beginning of the colon.

If you have Crohn's, these are some signs your symptoms may not be under control:

  • Taking special steps to accommodate your symptoms, such as:
    • Avoiding eating?
    • Making sure you always know where the nearest bathroom is?
    • Always carrying a change of clothes?
  • Counting on steroids for symptom relief

Still have questions about Crohn's disease?
Talk to your gastroenterologist.

Communication is an important part of your treatment and a great way to make sure you get the best care possible.

Important Safety Information about ENTYVIO® (vedolizumab)

  • Do not receive ENTYVIO if you have had an allergic reaction to ENTYVIO or any of its ingredients.
  • ENTYVIO may cause serious side effects, including:
    • Infusion and serious allergic reactions can happen while you are receiving ENTYVIO or several hours after treatment. You may need treatment if you have an allergic reaction. Tell your healthcare provider or get immediate medical help if you get any of these symptoms during or after an infusion of ENTYVIO: rash, itching, swelling of your lips, tongue, throat or face, shortness of breath or trouble breathing, wheezing, dizziness, feeling hot, or palpitations (feel like your heart is racing).
    • ENTYVIO may increase your risk of getting a serious infection. Before receiving and during treatment with ENTYVIO, tell your healthcare provider if you think you have an infection or symptoms of an infection, such as fever, chills, muscle aches, cough, shortness of breath, runny nose, sore throat, red or painful skin or sores on your body, tiredness, or pain during urination.
    • Although it has not been reported with ENTYVIO, it may be possible for a person to get progressive multifocal leukoencephalopathy (PML) (a rare, serious brain infection caused by a virus). People with weakened immune systems can get PML, which can result in death or severe disability. There is no known treatment, prevention, or cure for PML. Tell your healthcare provider right away if you have any of the following symptoms: confusion or problems thinking, loss of balance, change in the way you walk or talk, decreased strength or weakness on one side of the body, blurred vision, or loss of vision.
    • Liver problems can happen in people who receive ENTYVIO. Tell your healthcare provider right away if you have any of the following symptoms: tiredness, loss of appetite, pain on the right side of your abdomen, dark urine, or yellowing of the skin and eyes (jaundice).
  • The most common side effects of ENTYVIO include common cold, headache, joint pain, nausea, fever, infections of the nose and throat, tiredness, cough, bronchitis, flu, back pain, rash, itching, sinus infection, throat pain, and pain in extremities. These are not all the possible side effects of ENTYVIO. Call your healthcare provider for medical advice about side effects.
  • Before receiving ENTYVIO, tell your healthcare provider about all of your medical conditions, including if you: have or think you may have an infection or have infections that keep coming back; have liver problems; have tuberculosis (TB) or have been in close contact with someone with TB; have recently received or are scheduled to receive a vaccine; or if you are pregnant, breastfeeding, plan to become pregnant, or plan to breastfeed.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Uses of ENTYVIO® (vedolizumab)

ENTYVIO is a prescription medicine used in adults:

  • with moderate to severe ulcerative colitis (UC) when certain other UC medicines have not worked well enough or cannot be tolerated. ENTYVIO may help to: begin reducing some symptoms, induce and maintain remission, reduce or stop the use of corticosteroids, and improve the way the lining of your large intestine looks to your healthcare provider.
  • with moderate to severe Crohn's disease (CD) when certain other CD medicines have not worked well enough or cannot be tolerated. ENTYVIO may help to: begin reducing some symptoms, achieve remission, and reduce or stop the use of corticosteroids.

Please see the Full Prescribing Information, including the Medication Guide, for ENTYVIO and talk with your healthcare provider.

Important Safety Information about ENTYVIO® (vedolizumab)

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Uses of ENTYVIO® (vedolizumab)

ENTYVIO is a prescription medicine used in adults:

Please see the Full Prescribing Information, including the Medication Guide, for ENTYVIO and talk with your healthcare provider.