About Ulcerative Colitis

Understanding Ulcerative Colitis

900 Thousand
900K
Number of Americans affected by ulcerative colitis (UC). Ulcerative colitis may generally affect both men and women in their mid-30s.

The Causes of Ulcerative Colitis

It's unclear what causes ulcerative colitis. Studies indicate that it may be a combination of genetics, your immune system, and the environment. Ulcerative colitis tends to run in families, although researchers have yet to understand a clear pattern of inheritance. Diet and stress may aggravate ulcerative colitis, but they do not cause the disease on their own.

How Ulcerative Colitis Affects You

Ulcerative colitis is the result of an abnormal immune system response, during which your body mistakes certain bacteria and other materials in the intestine for foreign or invading substances. It then sends white blood cells into the intestines, where they create inflammation. Normally, this would cause a temporary inflammation that would resolve itself. But with ulcerative colitis, researchers believe that once your immune system is "turned on", it doesn't know how to "properly turn off". As a result, chronic inflammation damages the intestine and causes the symptoms of ulcerative colitis.

Unlike Crohn's disease which can affect all layers of the bowel wall, ulcerative colitis affects only the innermost lining of the colon.
How ulcerative colitis may affect you
While both ulcerative colitis and Crohn's disease are types of inflammatory bowel disease, the effects of ulcerative colitis are limited to the large intestine, which includes: rectum, descending colon, transverse colon, and ascending colon.

How is Ulcerative Colitis Affecting Your Day‑to‑day?

Ulcerative colitis is a chronic disease, and some patients may experience their disease worsening over time.

  • Even if you feel fine and symptoms are limited, there may still be active, damaging inflammation
  • Your ulcerative colitis may not be under control if you're taking special steps to accommodate your symptoms, such as:
    • Avoiding eating
    • Making sure you always know where the nearest bathroom is
    • Always carrying a change of clothes

It's important to understand how your condition is affecting you so you can explain it to your doctor. Use the doctor discussion guide to help you prepare for your discussion with your doctor.

Important Safety Information about ENTYVIO® (vedolizumab)

  • Do not receive ENTYVIO if you have had an allergic reaction to ENTYVIO or any of its ingredients.
  • ENTYVIO may cause serious side effects, including:
    • Infusion-related and serious allergic reactions can happen while you are receiving ENTYVIO or several hours after treatment. You may need treatment if you have an allergic reaction. Tell your healthcare provider or get immediate medical help if you get any of these symptoms during or after an infusion of ENTYVIO: rash, itching, swelling of your lips, tongue, throat or face, shortness of breath or trouble breathing, wheezing, dizziness, feeling hot, or palpitations (feel like your heart is racing).
    • ENTYVIO may increase your risk of getting a serious infection. Before receiving and during treatment with ENTYVIO, tell your healthcare provider if you think you have an infection or symptoms of an infection, such as fever, chills, muscle aches, cough, shortness of breath, runny nose, sore throat, red or painful skin or sores on your body, tiredness, or pain during urination.
    • People with weakened immune systems can get progressive multifocal leukoencephalopathy (PML) (a rare, serious brain infection caused by a virus). Although unlikely while receiving ENTYVIO, a risk of PML cannot be ruled out. PML can result in death or severe disability. There is no known treatment, prevention, or cure for PML. Tell your healthcare provider right away if you have any of the following symptoms: confusion or problems thinking, loss of balance, change in the way you walk or talk, decreased strength or weakness on one side of the body, blurred vision, or loss of vision.
    • Liver problems can happen in people who receive ENTYVIO. Tell your healthcare provider right away if you have any of the following symptoms: tiredness, loss of appetite, pain on the right side of your abdomen, dark urine, or yellowing of the skin and eyes (jaundice).
  • The most common side effects of ENTYVIO include common cold, headache, joint pain, nausea, fever, infections of the nose and throat, tiredness, cough, bronchitis, flu, back pain, rash, itching, sinus infection, throat pain, and pain in extremities. These are not all the possible side effects of ENTYVIO. Call your healthcare provider for medical advice about side effects.
  • Before receiving ENTYVIO, tell your healthcare provider about all of your medical conditions, including if you: have or think you may have an infection or have infections that keep coming back; have liver problems; have tuberculosis (TB) or have been in close contact with someone with TB; have recently received or are scheduled to receive a vaccine; or if you are pregnant, breastfeeding, plan to become pregnant, or plan to breastfeed.

Please see the full Prescribing Information, including the Medication Guide, for ENTYVIO and talk with your healthcare provider.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Uses of ENTYVIO® (vedolizumab)

ENTYVIO is a prescription medicine used in adults for the treatment of:

  • moderately to severely active ulcerative colitis
  • moderately to severely active Crohn’s disease

Important Safety Information about ENTYVIO® (vedolizumab)

Please see the full Prescribing Information, including the Medication Guide, for ENTYVIO and talk with your healthcare provider.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Uses of ENTYVIO® (vedolizumab)

ENTYVIO is a prescription medicine used in adults for the treatment of: