For adults with moderate to severe ulcerative colitis (UC).

#1 prescribed biologic for Crohn's and ulcerative colitis combined.

†Quarterly analysis of claims data from January 2023–December 2025.

Discover the only gut-focused treatment* for UC

that works right where U need it

*ENTYVIO helps block certain inflammation-causing cells from entering the gut.

Focus U Want

Helps block inflammation right where it occurs: In your gut


ENTYVIO helps block certain inflammation-causing cells from entering the gut.

How ENTYVIO works

Results U Need

Lasting relief and steroid-free remission for UC at 1 year†

Some people with UC experienced rapid symptom relief and visible improvement of the gut lining as early as 6 weeks†

Individual results may vary.

UC results

†Many patients taking ENTYVIO IV achieved remission at Week 52, some without steroids. Some achieved visible improvement of the gut lining and remission at Week 6. Remission is a measure to determine when a patient with Crohn’s or UC is experiencing few to no symptoms and an improvement in their condition.

Experience U Expect

Backed by 26 years of combined clinical research​​‡

Prescribed to people for more than 12 years​

Proven safety record across clinical trials​§

§Evaluated safety vs placebo in more than 3300 adults (UC, Crohn's, and healthy volunteers).

Explore your options
ENTYVIO vial and ENTYVIO Pen.

Support U Deserve

ENTYVIO starting at $0||

Wide coverage through both employer-provided and self‑purchased health insurance plans

Dedicated 1-on-1 support from nurse educators, injection training nurses, and patient mentors

Get Support

‡Based on a clinical trial of vedolizumab initiated in 2000.

||For eligible patients only. Terms & conditions apply.

Coverage of ENTYVIO as of December 2025.

IV=intravenous.

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Discover ENTYVIO for Ulcerative Colitis

ENTYVIO (vedolizumab) is a biologic used to treat moderate to severe ulcerative colitis after other medications have stopped working.

You can explore more information about ENTYVIO for UC, including results from UC patients, personal treatment stories, financial assistance options, and additional resources.

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