Ulcerative Colitis Treatment Options

Overview of treatment options for ulcerative colitis

ENTYVIO is for adults with moderate to severe ulcerative colitis (UC)

Patient Portrayal

Conventional treatment options

  • 5-Aminosalicylic Acids (5-ASAs)

    A class of drugs that reduces inflammation in the lining of the GI tract. They are most commonly used for the treatment of mild to moderate ulcerative colitis symptoms.

  • Corticosteroids

    A class of drugs that works to lower the activity of the immune system, thereby decreasing the inflammatory response. They are not typically used long term.

  • Immunomodulators

    A class of drugs that modifies the immune system's ability to cause ongoing inflammation. They are typically used when 5-ASAs and corticosteroids don't relieve symptoms.

Advanced therapy options

Advanced therapies are used after conventional therapies.


  • Anti-Integrins
    Anti-α4β7 integrins, such as ENTYVIO, block gut-directed white blood cells involved in the inflammatory response from moving out of the blood vessels and into the gut tissue by blocking a protein on the surface of these cells.
  • Anti-TNFα
    Bind and block a protein called tumor necrosis factor alpha (TNFα), which promotes inflammation in the intestine.
  • Anti-Interleukins
    Block interleukin proteins, which are associated with the inflammation process.


  • JAK (Janus Kinase) Inhibitors
    Block JAK enzymes involved in inflammation.
  • S1P (sphingosine-1-phosphate) Receptor Modulators
    Block a type of white blood cell called lymphocytes from moving out of the lymph nodes and into the bloodstream.

Having a thorough discussion about the benefits and risks of all available medications with your doctor can help you understand what treatments may be appropriate for you.

How ENTYVIO works

Curious how ENTYVIO helps fight UC? Here’s an easy-to-understand description.

See the science