Treatment Options for UC

ENTYVIO is for adults with moderate to severe ulcerative colitis when certain other medications haven't worked well enough or can't be tolerated.

Overview of Treatment Options for Ulcerative Colitis

Conventional Treatment Options

5-Aminosalicylic Acids (5-ASAs)

A class of drugs that reduces inflammation in the lining of the GI tract. They are most commonly used for the treatment of mild to moderate ulcerative colitis symptoms.


A class of drugs that works quickly to lower the activity of the immune system, thereby decreasing the inflammatory response. They are not typically used long term and should not be stopped abruptly.


A class of drugs that modifies the immune system's ability to cause ongoing inflammation. They are typically used when 5-ASAs and corticosteroids don't relieve symptoms.

Advanced Therapy Options

Advanced therapies are used after conventional therapies

Types of Biologics:

  • Anti-Integrins Anti-α4β7 integrins, such as ENTYVIO, block gut-directed white blood cells involved in the inflammatory response from moving out of the blood vessels and into the gut tissue by blocking a protein on the surface of these cells.
  • Anti-TNFα Bind and block a protein called tumor necrosis factor alpha (TNFα), which promotes inflammation in the intestine.
  • Anti-Interleukins Block interleukin proteins, which are associated with the inflammation process.

Types of Small Molecule Treatments:

  • JAK Inhibitors Block Janus Kinase (JAK) enzymes involved in inflammation.
  • S1P (sphingosine-1-phosphate) Receptor Modulators Block a type of white blood cell called lymphocytes from moving out of the lymph nodes and into the bloodstream.

Having a thorough discussion about the benefits and risks of all available medications with your doctor can help you understand what treatments may be appropriate for you.