Treatment Options for UC

Overview of Treatment Options for Ulcerative Colitis

Conventional Treatment Options

5-Aminosalicylic Acids (5-ASAs)

A class of drugs that reduce inflammation in the lining of the GI tract. They are most commonly used for the treatment of mild to moderate ulcerative colitis symptoms.

Corticosteroids

A class of drugs that work quickly to lower the activity of the immune system, thereby decreasing the inflammatory response. They are not typically used long-term and should not be stopped abruptly.

Immunomodulators

A class of drugs that modify the immune system's ability to cause ongoing inflammation. They are typically used when 5-ASAs and corticosteroids don't relieve symptoms.

Advanced Therapy Options

Advanced therapies are used after conventional therapies

Anti-Integrins

Anti-α4β7 integrins block gut-directed white blood cells involved in the inflammatory response from moving out of the blood vessels and into the gut tissue by blocking a protein on the surface of these cells.

TNFα Blockers

Bind and block a protein called tumor necrosis factor alpha (TNFα), which promotes inflammation in the intestine.

Anti-Interleukins

Block interleukin proteins, which are associated with the inflammation process.

JAK Inhibitors

Block Janus kinase (JAK) enzymes involved in inflammation.

Having a thorough discussion about the benefits and risks of all available medications with your doctor can help you understand what treatments may be appropriate for you.

Important Safety Information about ENTYVIO® (vedolizumab)

  • Do not receive ENTYVIO if you have had an allergic reaction to ENTYVIO or any of its ingredients.
  • ENTYVIO may cause serious side effects, including:
    • Infusion-related and serious allergic reactions can happen while you are receiving ENTYVIO or several hours after treatment. You may need treatment if you have an allergic reaction. Tell your healthcare provider or get immediate medical help if you get any of these symptoms during or after an infusion of ENTYVIO: rash, itching, swelling of your lips, tongue, throat or face, shortness of breath or trouble breathing, wheezing, dizziness, feeling hot, or palpitations (feel like your heart is racing).
    • ENTYVIO may increase your risk of getting a serious infection. Before receiving and during treatment with ENTYVIO, tell your healthcare provider if you think you have an infection or symptoms of an infection, such as fever, chills, muscle aches, cough, shortness of breath, runny nose, sore throat, red or painful skin or sores on your body, tiredness, or pain during urination.
    • People with weakened immune systems can get progressive multifocal leukoencephalopathy (PML) (a rare, serious brain infection caused by a virus). Although unlikely while receiving ENTYVIO, a risk of PML cannot be ruled out. PML can result in death or severe disability. There is no known treatment, prevention, or cure for PML. Tell your healthcare provider right away if you have any of the following symptoms: confusion or problems thinking, loss of balance, change in the way you walk or talk, decreased strength or weakness on one side of the body, blurred vision, or loss of vision.
    • Liver problems can happen in people who receive ENTYVIO. Tell your healthcare provider right away if you have any of the following symptoms: tiredness, loss of appetite, pain on the right side of your abdomen, dark urine, or yellowing of the skin and eyes (jaundice).
  • The most common side effects of ENTYVIO include common cold, headache, joint pain, nausea, fever, infections of the nose and throat, tiredness, cough, bronchitis, flu, back pain, rash, itching, sinus infection, throat pain, and pain in extremities. These are not all the possible side effects of ENTYVIO. Call your healthcare provider for medical advice about side effects.
  • Before receiving ENTYVIO, tell your healthcare provider about all of your medical conditions, including if you: have or think you may have an infection or have infections that keep coming back; have liver problems; have tuberculosis (TB) or have been in close contact with someone with TB; have recently received or are scheduled to receive a vaccine; or if you are pregnant, breastfeeding, plan to become pregnant, or plan to breastfeed.

Please see the full Prescribing Information, including the Medication Guide, for ENTYVIO and talk with your healthcare provider.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Uses of ENTYVIO® (vedolizumab)

ENTYVIO is a prescription medicine used in adults for the treatment of:

  • moderately to severely active ulcerative colitis
  • moderately to severely active Crohn’s disease

Important Safety Information about ENTYVIO® (vedolizumab)

Please see the full Prescribing Information, including the Medication Guide, for ENTYVIO and talk with your healthcare provider.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Uses of ENTYVIO® (vedolizumab)

ENTYVIO is a prescription medicine used in adults for the treatment of: