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FOCUS WHERE UC
HITS YOU HARD

The #1 most prescribed biologic in CD and UC new-start patients^*

GUT-FOCUSED ENTYVIO

IS MADE FOR YOU.

ENTYVIO is for adults with moderate to severe ulcerative colitisCrohn's disease when certain other medications haven't worked well enough or can't be tolerated.

Based on patient counts every month from April 2020 to March 2021. "New starts" includes patients who had not taken a biologic in the last 3 years, patients who switched their biologic to ENTYVIO in the past 3 years, and patients who stayed on ENTYVIO for the past 3 years.

Uses of ENTYVIO^® (vedolizumab)

ENTYVIO is a prescription medicine used in adults for the treatment of:

moderately to severely active ulcerative colitis
moderately to severely active Crohn’s disease

Important Safety Information about ENTYVIO^® (vedolizumab)

Do not receive ENTYVIO if you have had an allergic reaction to ENTYVIO or any of its ingredients.
ENTYVIO may cause serious side effects, including:
- Infusion-related and serious allergic reactions can happen while you are receiving ENTYVIO or several hours after treatment. You may need treatment if you have an allergic reaction. Tell your healthcare provider or get immediate medical help if you get any of these symptoms during or after an infusion of ENTYVIO: rash, itching, swelling of your lips, tongue, throat or face, shortness of breath or trouble breathing, wheezing, dizziness, feeling hot, or palpitations (feel like your heart is racing).
- ENTYVIO may increase your risk of getting a serious infection. Before receiving and during treatment with ENTYVIO, tell your healthcare provider if you think you have an infection or symptoms of an infection, such as fever, chills, muscle aches, cough, shortness of breath, runny nose, sore throat, red or painful skin or sores on your body, tiredness, or pain during urination.
- People with weakened immune systems can get progressive multifocal leukoencephalopathy (PML) (a rare, serious brain infection caused by a virus). Although unlikely while receiving ENTYVIO, a risk of PML cannot be ruled out. PML can result in death or severe disability. There is no known treatment, prevention, or cure for PML. Tell your healthcare provider right away if you have any of the following symptoms: confusion or problems thinking, loss of balance, change in the way you walk or talk, decreased strength or weakness on one side of the body, blurred vision, or loss of vision.
- Liver problems can happen in people who receive ENTYVIO. Tell your healthcare provider right away if you have any of the following symptoms: tiredness, loss of appetite, pain on the right side of your abdomen, dark urine, or yellowing of the skin and eyes (jaundice).
The most common side effects of ENTYVIO include common cold, headache, joint pain, nausea, fever, infections of the nose and throat, tiredness, cough, bronchitis, flu, back pain, rash, itching, sinus infection, throat pain, and pain in extremities. These are not all the possible side effects of ENTYVIO. Call your healthcare provider for medical advice about side effects.
Before receiving ENTYVIO, tell your healthcare provider about all of your medical conditions, including if you: have or think you may have an infection or have infections that keep coming back; have liver problems; have tuberculosis (TB) or have been in close contact with someone with TB; have recently received or are scheduled to receive a vaccine; or if you are pregnant, breastfeeding, plan to become pregnant, or plan to breastfeed.

Please see the full Prescribing Information, including the Medication Guide, for ENTYVIO and talk with your healthcare provider.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Uses of ENTYVIO^® (vedolizumab)

ENTYVIO is a prescription medicine used in adults for the treatment of:

moderately to severely active ulcerative colitis
moderately to severely active Crohn’s disease

Important Safety Information about ENTYVIO^® (vedolizumab)

Do not receive ENTYVIO if you have had an allergic reaction to ENTYVIO or any of its ingredients.
ENTYVIO may cause serious side effects, including:
- Infusion-related and serious allergic reactions can happen while you are receiving ENTYVIO or several hours after treatment. You may need treatment if you have an allergic reaction. Tell your healthcare provider or get immediate medical help if you get any of these symptoms during or after an infusion of ENTYVIO: rash, itching, swelling of your lips, tongue, throat or face, shortness of breath or trouble breathing, wheezing, dizziness, feeling hot, or palpitations (feel like your heart is racing).
- ENTYVIO may increase your risk of getting a serious infection. Before receiving and during treatment with ENTYVIO, tell your healthcare provider if you think you have an infection or symptoms of an infection, such as fever, chills, muscle aches, cough, shortness of breath, runny nose, sore throat, red or painful skin or sores on your body, tiredness, or pain during urination.
- People with weakened immune systems can get progressive multifocal leukoencephalopathy (PML) (a rare, serious brain infection caused by a virus). Although unlikely while receiving ENTYVIO, a risk of PML cannot be ruled out. PML can result in death or severe disability. There is no known treatment, prevention, or cure for PML. Tell your healthcare provider right away if you have any of the following symptoms: confusion or problems thinking, loss of balance, change in the way you walk or talk, decreased strength or weakness on one side of the body, blurred vision, or loss of vision.
- Liver problems can happen in people who receive ENTYVIO. Tell your healthcare provider right away if you have any of the following symptoms: tiredness, loss of appetite, pain on the right side of your abdomen, dark urine, or yellowing of the skin and eyes (jaundice).
The most common side effects of ENTYVIO include common cold, headache, joint pain, nausea, fever, infections of the nose and throat, tiredness, cough, bronchitis, flu, back pain, rash, itching, sinus infection, throat pain, and pain in extremities. These are not all the possible side effects of ENTYVIO. Call your healthcare provider for medical advice about side effects.
Before receiving ENTYVIO, tell your healthcare provider about all of your medical conditions, including if you: have or think you may have an infection or have infections that keep coming back; have liver problems; have tuberculosis (TB) or have been in close contact with someone with TB; have recently received or are scheduled to receive a vaccine; or if you are pregnant, breastfeeding, plan to become pregnant, or plan to breastfeed.

Please see the full Prescribing Information, including the Medication Guide, for ENTYVIO and talk with your healthcare provider.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Uses of ENTYVIO^® (vedolizumab)

ENTYVIO is a prescription medicine used in adults for the treatment of:

moderately to severely active ulcerative colitis
moderately to severely active Crohn’s disease

†*

The EntyvioConnect Co-Pay Program ("Co-Pay Program") provides financial support for commercially insured patients who qualify for the Co-Pay Program. The Co-Pay Program cannot be used if patient is a beneficiary of, or any part of the prescription is covered by: 1) any federal, state, or government-funded healthcare program (Medicare, Medicare Advantage, Medicaid, TRICARE, etc.), including a state pharmaceutical assistance program (the Federal Employees Health Benefit (FEHB) Program is not a government-funded healthcare program for the purpose of this offer), 2) the Medicare Prescription Drug Program (Part D), or if patient is currently in the coverage gap, or 3) insurance that is paying the entire cost of the prescription. Offer not valid for patients under 18 years of age. Takeda reserves the right to change or end the Co-Pay Program at any time without notice, and other terms and conditions may apply. Please click here to see the full terms and conditions.

Uses of ENTYVIO^® (vedolizumab)

See How
ENTYVIO Compared to HUMIRA^® (adalimumab)HUMIRA^® AbbVie, Inc. North Chicago, IL.

Eligible Patients May
Pay as Little as $5 Per Dose of ENTYVIOMust meet eligibility requirements^†

Connect with a
Dedicated
Nurse
Educator

Find a Gastroenterologist
Who Treats
Ulcerative Colitis

Uses of ENTYVIO® (vedolizumab)

See How ENTYVIO Compared to HUMIRA® (adalimumab)HUMIRA® AbbVie, Inc. North Chicago, IL.

Eligible Patients May Pay as Little as $5 Per Dose of ENTYVIOMust meet eligibility requirements†

Connect with a Dedicated Nurse Educator

Find a Gastroenterologist Who Treats Ulcerative Colitis

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Uses of ENTYVIO^® (vedolizumab)

See How
ENTYVIO Compared to HUMIRA^® (adalimumab)HUMIRA^® AbbVie, Inc. North Chicago, IL.

Eligible Patients May
Pay as Little as $5 Per Dose of ENTYVIOMust meet eligibility requirements^†

Connect with a
Dedicated
Nurse
Educator

Find a Gastroenterologist
Who Treats
Ulcerative Colitis